2021 American Athletic Conference Leaders Scoring Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | East Carolina University | 1 | 2 | 2 | 2 | 0 | 0 | 20 | 20.0 |
| 1 | University of Memphis | 1 | 4 | 1 | 2 | 0 | 0 | 29 | 29.0 |
| 3 | Southern Methodist University | 1 | 4 | 2 | 4 | 0 | 0 | 34 | 34.0 |
| 4 | University of Cincinnati | 2 | 6 | 3 | 6 | 0 | 0 | 51 | 25.5 |
| 4 | University of Houston | 2 | 6 | 3 | 6 | 0 | 0 | 51 | 25.5 |
| 6 | University of Central Florida | 2 | 8 | 1 | 8 | 0 | 0 | 59 | 29.5 |
| 7 | The University of Tulsa | 2 | 9 | 2 | 9 | 0 | 0 | 69 | 34.5 |
| 8 | Tulane University | 2 | 13 | 4 | 11 | 0 | 0 | 101 | 50.5 |
| 9 | University of South Florida | 2 | 12 | 1 | 12 | 0 | 0 | 87 | 43.5 |
| 9 | Temple University | 2 | 12 | 1 | 12 | 0 | 1 | 89 | 44.5 |