2021 American Athletic Conference Leaders Scoring Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 11 | 21 | 10 | 18 | 1 | 1 | 178 | 16.2 |
| 2 | Houston | 11 | 30 | 8 | 27 | 2 | 0 | 235 | 21.4 |
| 3 | Tulsa | 10 | 32 | 11 | 29 | 2 | 0 | 258 | 25.8 |
| 3 | East Carolina | 10 | 35 | 8 | 29 | 2 | 0 | 267 | 26.7 |
| 5 | UCF | 10 | 30 | 12 | 30 | 0 | 0 | 246 | 24.6 |
| 6 | SMU | 10 | 39 | 10 | 34 | 0 | 0 | 298 | 29.8 |
| 7 | Tulane | 9 | 37 | 10 | 35 | 0 | 0 | 287 | 31.9 |
| 8 | Memphis | 10 | 38 | 13 | 36 | 1 | 0 | 305 | 30.5 |
| 9 | South Florida | 9 | 41 | 9 | 37 | 0 | 1 | 312 | 34.7 |
| 10 | Navy | 12 | 43 | 11 | 40 | 2 | 2 | 339 | 28.3 |
| 11 | Temple | 9 | 46 | 11 | 43 | 1 | 0 | 354 | 39.3 |