2021 American Athletic Conference Leaders Scoring Defense - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Tulane | 2 | 6 | 2 | 5 | 0 | 0 | 47 | 23.5 |
| 2 | Navy | 2 | 7 | 0 | 7 | 0 | 0 | 49 | 24.5 |
| 3 | Cincinnati | 5 | 10 | 5 | 10 | 0 | 1 | 87 | 17.4 |
| 3 | East Carolina | 5 | 15 | 2 | 10 | 2 | 0 | 110 | 22.0 |
| 5 | South Florida | 3 | 14 | 1 | 14 | 0 | 0 | 101 | 33.7 |
| 6 | Houston | 8 | 17 | 7 | 15 | 2 | 0 | 142 | 17.8 |
| 6 | Tulsa | 7 | 18 | 9 | 15 | 2 | 0 | 154 | 22.0 |
| 6 | Memphis | 4 | 16 | 6 | 15 | 0 | 0 | 129 | 32.3 |
| 9 | UCF | 8 | 18 | 7 | 18 | 0 | 0 | 147 | 18.4 |
| 10 | SMU | 7 | 23 | 7 | 19 | 0 | 0 | 178 | 25.4 |
| 11 | Temple | 6 | 28 | 6 | 26 | 1 | 1 | 216 | 36.0 |