2021 American Athletic Conference Leaders Total Defense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 9 | 1289 | 1449 | 631 | 2738 | 4.34 | 304.2 |
| 2 | East Carolina | 8 | 1270 | 1475 | 488 | 2745 | 5.63 | 343.1 |
| 3 | Navy | 8 | 1021 | 1818 | 454 | 2839 | 6.25 | 354.9 |
| 4 | Houston | 9 | 984 | 1967 | 572 | 2951 | 5.16 | 327.9 |
| 5 | Tulsa | 8 | 1194 | 1791 | 558 | 2985 | 5.35 | 373.1 |
| 6 | UCF | 8 | 1493 | 1558 | 596 | 3051 | 5.12 | 381.4 |
| 7 | Memphis | 8 | 1553 | 1617 | 590 | 3170 | 5.37 | 396.3 |
| 8 | SMU | 8 | 1105 | 2113 | 555 | 3218 | 5.80 | 402.3 |
| 9 | Tulane | 8 | 1176 | 2182 | 582 | 3358 | 5.77 | 419.8 |
| 10 | South Florida | 8 | 1556 | 2072 | 546 | 3628 | 6.64 | 453.5 |
| 11 | Temple | 8 | 1953 | 1704 | 593 | 3657 | 6.17 | 457.1 |