2021 American Athletic Conference Leaders Total Defense - Games in December/January Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Navy | 1 | 124 | 108 | 49 | 232 | 4.73 | 232.0 |
| 2 | Tulsa | 1 | 71 | 176 | 47 | 247 | 5.26 | 247.0 |
| 3 | UCF | 1 | 205 | 171 | 67 | 376 | 5.61 | 376.0 |
| 4 | Houston | 2 | 335 | 417 | 111 | 752 | 6.77 | 376.0 |
| 5 | Cincinnati | 2 | 387 | 431 | 148 | 818 | 5.53 | 409.0 |