2021 Atlantic Coast Conference Leaders Total Offense - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Wake Forest | 13 | 2086 | 4051 | 1024 | 6137 | 5.99 | 472.1 |
| 2 | Pittsburgh | 13 | 1837 | 4268 | 987 | 6105 | 6.19 | 469.6 |
| 3 | Duke | 11 | 2016 | 2572 | 863 | 4588 | 5.32 | 417.1 |
| 4 | Virginia | 11 | 1279 | 4372 | 828 | 5651 | 6.82 | 513.7 |
| 4 | Clemson | 12 | 1942 | 2223 | 828 | 4165 | 5.03 | 347.1 |
| 6 | North Carolina | 12 | 2463 | 3110 | 827 | 5573 | 6.74 | 464.4 |
| 7 | Louisville | 12 | 2610 | 2777 | 809 | 5387 | 6.66 | 448.9 |
| 7 | Miami (Florida) | 11 | 1210 | 3437 | 809 | 4647 | 5.74 | 422.5 |
| 9 | Virginia Tech | 12 | 2299 | 2081 | 786 | 4380 | 5.57 | 365.0 |
| 10 | North Carolina State | 11 | 1296 | 3174 | 747 | 4470 | 5.98 | 406.4 |
| 11 | Georgia Tech | 11 | 1869 | 2126 | 727 | 3995 | 5.50 | 363.2 |
| 12 | Boston College | 11 | 1793 | 1870 | 718 | 3663 | 5.10 | 333.0 |
| 13 | Florida State | 11 | 1933 | 2286 | 715 | 4219 | 5.90 | 383.5 |
| 14 | Syracuse | 11 | 2276 | 1499 | 712 | 3775 | 5.30 | 343.2 |