2021 Atlantic Coast Conference Leaders Total Offense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 5 | 766 | 1073 | 370 | 1839 | 4.97 | 367.8 |
| 2 | Pittsburgh | 5 | 750 | 1716 | 363 | 2466 | 6.79 | 493.2 |
| 3 | Louisville | 5 | 880 | 1196 | 340 | 2076 | 6.11 | 415.2 |
| 3 | Virginia Tech | 5 | 685 | 918 | 340 | 1603 | 4.71 | 320.6 |
| 5 | Duke | 4 | 993 | 1189 | 323 | 2182 | 6.76 | 545.5 |
| 6 | Miami (Florida) | 4 | 636 | 1184 | 292 | 1820 | 6.23 | 455.0 |
| 7 | North Carolina State | 4 | 712 | 1073 | 277 | 1785 | 6.44 | 446.3 |
| 8 | Florida State | 4 | 973 | 735 | 271 | 1708 | 6.30 | 427.0 |
| 9 | Virginia | 4 | 637 | 1330 | 265 | 1967 | 7.42 | 491.8 |
| 10 | North Carolina | 4 | 858 | 1166 | 260 | 2024 | 7.78 | 506.0 |
| 11 | Boston College | 4 | 882 | 802 | 259 | 1684 | 6.50 | 421.0 |
| 12 | Wake Forest | 4 | 653 | 1202 | 258 | 1855 | 7.19 | 463.8 |
| 12 | Syracuse | 4 | 864 | 705 | 258 | 1569 | 6.08 | 392.3 |
| 14 | Georgia Tech | 4 | 655 | 581 | 251 | 1236 | 4.92 | 309.0 |