2021 Louisville Cardinals Opponent First Down Split Stats through 01/10/2022
| Split | G | Rush | Pass | Penalty | Total |
|---|---|---|---|---|---|
| All Games | 13 | 117 | 146 | 25 | 288 |
| at Home | 7 | 60 | 67 | 15 | 142 |
| on Road/Neutral Site | 6 | 57 | 79 | 10 | 146 |
| in Wins | 6 | 53 | 51 | 14 | 118 |
| in Losses | 7 | 64 | 95 | 11 | 170 |
| vs. Conference | 8 | 59 | 98 | 17 | 174 |
| vs. Non-Conference | 5 | 58 | 48 | 8 | 114 |
| vs. Ranked (AP) | 5 | 52 | 65 | 9 | 126 |
| vs. Unranked (AP) | 8 | 65 | 81 | 16 | 162 |
| vs. FBS (I-A) | 12 | 113 | 139 | 22 | 274 |
| vs. FCS (I-AA) | 1 | 4 | 7 | 3 | 14 |
| vs. FBS Winning | 7 | 75 | 80 | 11 | 166 |
| vs. FBS Non-Winning | 5 | 38 | 59 | 11 | 108 |
| vs. FBS Power 5 | 10 | 90 | 124 | 20 | 234 |
| vs. FBS non-Power 5 | 2 | 23 | 15 | 2 | 40 |
| in August/September | 4 | 39 | 41 | 10 | 90 |
| in October | 4 | 21 | 60 | 7 | 88 |
| in November | 4 | 46 | 38 | 8 | 92 |
| in December/January | 1 | 11 | 7 | 0 | 18 |