2021 Atlantic Coast Conference Leaders Passing Defense - Games in December/January Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 1 | 39 | 23 | 59.0 | 204 | 5.2 | 1 | 1 | 106.24 | 39.0 | 204.0 |
| 2 | Wake Forest | 2 | 67 | 39 | 58.2 | 438 | 6.5 | 2 | 2 | 117.00 | 33.5 | 219.0 |
| 2 | Louisville | 1 | 9 | 8 | 88.9 | 239 | 26.6 | 2 | 0 | 385.29 | 9.0 | 239.0 |
| 2 | North Carolina | 1 | 15 | 12 | 80.0 | 242 | 16.1 | 2 | 0 | 259.52 | 15.0 | 242.0 |
| 2 | Virginia Tech | 1 | 25 | 21 | 84.0 | 275 | 11.0 | 2 | 0 | 202.80 | 25.0 | 275.0 |
| 6 | Pittsburgh | 2 | 96 | 50 | 52.1 | 567 | 5.9 | 5 | 5 | 108.46 | 48.0 | 283.5 |