2021 Atlantic Coast Conference Leaders Passing Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 5 | 170 | 88 | 51.8 | 754 | 4.4 | 1 | 7 | 82.72 | 34.0 | 150.8 |
| 2 | North Carolina | 4 | 81 | 52 | 64.2 | 655 | 8.1 | 4 | 2 | 143.48 | 20.3 | 163.8 |
| 2 | Boston College | 4 | 114 | 71 | 62.3 | 762 | 6.7 | 4 | 6 | 119.48 | 28.5 | 190.5 |
| 4 | Syracuse | 4 | 102 | 75 | 73.5 | 704 | 6.9 | 5 | 1 | 145.73 | 25.5 | 176.0 |
| 5 | Wake Forest | 4 | 115 | 65 | 56.5 | 666 | 5.8 | 6 | 6 | 111.95 | 28.8 | 166.5 |
| 5 | North Carolina State | 4 | 147 | 83 | 56.5 | 906 | 6.2 | 6 | 6 | 113.54 | 36.8 | 226.5 |
| 7 | Virginia | 4 | 121 | 74 | 61.2 | 833 | 6.9 | 7 | 2 | 134.77 | 30.3 | 208.3 |
| 7 | Louisville | 5 | 124 | 91 | 73.4 | 1122 | 9.0 | 7 | 3 | 163.18 | 24.8 | 224.4 |
| 7 | Duke | 4 | 122 | 69 | 56.6 | 963 | 7.9 | 7 | 5 | 133.60 | 30.5 | 240.8 |
| 10 | Virginia Tech | 5 | 141 | 92 | 65.2 | 1049 | 7.4 | 8 | 4 | 140.80 | 28.2 | 209.8 |
| 10 | Florida State | 4 | 137 | 79 | 57.7 | 955 | 7.0 | 8 | 6 | 126.73 | 34.3 | 238.8 |
| 12 | Georgia Tech | 4 | 83 | 51 | 61.4 | 804 | 9.7 | 9 | 2 | 173.78 | 20.8 | 201.0 |
| 12 | Pittsburgh | 5 | 175 | 101 | 57.7 | 1176 | 6.7 | 9 | 3 | 127.70 | 35.0 | 235.2 |
| 12 | Miami (Florida) | 4 | 141 | 86 | 61.0 | 983 | 7.0 | 9 | 2 | 137.77 | 35.3 | 245.8 |