2021 Atlantic Coast Conference Leaders Passing Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Virginia Tech | 2 | 63 | 37 | 58.7 | 424 | 6.7 | 4 | 2 | 129.86 | 31.5 | 212.0 |
| 2 | North Carolina State | 2 | 73 | 32 | 43.8 | 401 | 5.5 | 5 | 4 | 101.62 | 36.5 | 200.5 |
| 2 | Pittsburgh | 3 | 128 | 65 | 50.8 | 718 | 5.6 | 5 | 7 | 99.85 | 42.7 | 239.3 |
| 4 | Boston College | 3 | 84 | 49 | 58.3 | 694 | 8.3 | 6 | 1 | 148.92 | 28.0 | 231.3 |
| 4 | Duke | 2 | 85 | 53 | 62.4 | 827 | 9.7 | 6 | 0 | 167.36 | 42.5 | 413.5 |
| 6 | Clemson | 4 | 158 | 107 | 67.7 | 1045 | 6.6 | 7 | 2 | 135.37 | 39.5 | 261.3 |
| 7 | Wake Forest | 3 | 113 | 70 | 61.9 | 891 | 7.9 | 8 | 3 | 146.23 | 37.7 | 297.0 |
| 8 | Louisville | 5 | 158 | 103 | 65.2 | 1391 | 8.8 | 9 | 1 | 156.67 | 31.6 | 278.2 |
| 9 | Syracuse | 4 | 130 | 86 | 66.2 | 1040 | 8.0 | 10 | 2 | 155.65 | 32.5 | 260.0 |
| 9 | Georgia Tech | 4 | 108 | 74 | 68.5 | 1082 | 10.0 | 10 | 0 | 183.23 | 27.0 | 270.5 |
| 11 | Florida State | 4 | 129 | 88 | 68.2 | 1128 | 8.7 | 11 | 4 | 163.61 | 32.3 | 282.0 |
| 12 | Virginia | 4 | 131 | 83 | 63.4 | 1133 | 8.6 | 13 | 3 | 164.18 | 32.8 | 283.3 |
| 12 | Miami (Florida) | 4 | 168 | 109 | 64.9 | 1444 | 8.6 | 13 | 2 | 160.24 | 42.0 | 361.0 |
| 14 | North Carolina | 4 | 153 | 87 | 56.9 | 1221 | 8.0 | 14 | 3 | 150.17 | 38.3 | 305.3 |