2021 Atlantic Coast Conference Leaders Opponent Penalties - Games in November Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Wake Forest | 4 | 36 | 350 | 9.0 | 87.5 |
| 2 | Boston College | 4 | 37 | 330 | 9.3 | 82.5 |
| 3 | Florida State | 4 | 40 | 320 | 10.0 | 80.0 |
| 4 | Miami (Florida) | 4 | 31 | 283 | 7.8 | 70.8 |
| 5 | Pittsburgh | 4 | 34 | 277 | 8.5 | 69.3 |
| 6 | North Carolina | 4 | 30 | 261 | 7.5 | 65.3 |
| 7 | Virginia | 3 | 22 | 181 | 7.3 | 60.3 |
| 8 | Duke | 4 | 29 | 235 | 7.3 | 58.8 |
| 9 | Syracuse | 3 | 20 | 176 | 6.7 | 58.7 |
| 10 | Virginia Tech | 4 | 23 | 214 | 5.8 | 53.5 |
| 11 | North Carolina State | 4 | 23 | 207 | 5.8 | 51.8 |
| 12 | Clemson | 4 | 28 | 178 | 7.0 | 44.5 |
| 13 | Georgia Tech | 4 | 14 | 155 | 3.5 | 38.8 |
| 14 | Louisville | 4 | 19 | 146 | 4.8 | 36.5 |