2021 Atlantic Coast Conference Leaders Opponent Penalties - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Florida State | 4 | 39 | 317 | 9.8 | 79.3 |
| 2 | Pittsburgh | 5 | 38 | 362 | 7.6 | 72.4 |
| 3 | Miami (Florida) | 4 | 30 | 269 | 7.5 | 67.3 |
| 4 | Clemson | 5 | 42 | 324 | 8.4 | 64.8 |
| 5 | Duke | 4 | 25 | 230 | 6.3 | 57.5 |
| 6 | Virginia Tech | 5 | 32 | 287 | 6.4 | 57.4 |
| 7 | North Carolina State | 4 | 26 | 225 | 6.5 | 56.3 |
| 8 | Virginia | 4 | 23 | 222 | 5.8 | 55.5 |
| 9 | Louisville | 5 | 30 | 259 | 6.0 | 51.8 |
| 10 | Wake Forest | 4 | 27 | 199 | 6.8 | 49.8 |
| 10 | Syracuse | 4 | 19 | 199 | 4.8 | 49.8 |
| 12 | Boston College | 4 | 21 | 168 | 5.3 | 42.0 |
| 13 | Georgia Tech | 4 | 18 | 144 | 4.5 | 36.0 |
| 14 | North Carolina | 4 | 19 | 130 | 4.8 | 32.5 |