2021 Atlantic Coast Conference Leaders Opponent Penalties - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Clemson | 4 | 37 | 321 | 9.3 | 80.3 |
| 2 | Miami (Florida) | 4 | 32 | 315 | 8.0 | 78.8 |
| 3 | Wake Forest | 3 | 26 | 219 | 8.7 | 73.0 |
| 4 | North Carolina State | 2 | 18 | 144 | 9.0 | 72.0 |
| 4 | Virginia Tech | 2 | 16 | 144 | 8.0 | 72.0 |
| 6 | Boston College | 3 | 21 | 205 | 7.0 | 68.3 |
| 7 | North Carolina | 4 | 30 | 270 | 7.5 | 67.5 |
| 8 | Syracuse | 4 | 28 | 256 | 7.0 | 64.0 |
| 9 | Louisville | 5 | 32 | 264 | 6.4 | 52.8 |
| 10 | Pittsburgh | 3 | 19 | 151 | 6.3 | 50.3 |
| 11 | Florida State | 4 | 27 | 200 | 6.8 | 50.0 |
| 12 | Virginia | 4 | 23 | 192 | 5.8 | 48.0 |
| 13 | Duke | 2 | 11 | 87 | 5.5 | 43.5 |
| 14 | Georgia Tech | 4 | 17 | 163 | 4.3 | 40.8 |