2021 Atlantic Coast Conference Leaders Opponent Penalties - Games in October Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Miami (Florida) | 3 | 25 | 256 | 8.3 | 85.3 |
| 2 | Clemson | 4 | 36 | 309 | 9.0 | 77.3 |
| 3 | Virginia Tech | 4 | 30 | 266 | 7.5 | 66.5 |
| 4 | Wake Forest | 4 | 24 | 235 | 6.0 | 58.8 |
| 5 | Boston College | 4 | 26 | 234 | 6.5 | 58.5 |
| 6 | North Carolina | 4 | 26 | 226 | 6.5 | 56.5 |
| 6 | Virginia | 4 | 23 | 226 | 5.8 | 56.5 |
| 8 | Florida State | 4 | 29 | 224 | 7.3 | 56.0 |
| 9 | North Carolina State | 4 | 29 | 222 | 7.3 | 55.5 |
| 10 | Georgia Tech | 4 | 23 | 219 | 5.8 | 54.8 |
| 11 | Pittsburgh | 4 | 21 | 198 | 5.3 | 49.5 |
| 12 | Louisville | 4 | 23 | 181 | 5.8 | 45.3 |
| 13 | Duke | 4 | 23 | 178 | 5.8 | 44.5 |
| 14 | Syracuse | 5 | 17 | 160 | 3.4 | 32.0 |