2021 Atlantic Coast Conference Leaders Passing Defense - Games in October Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Florida State | 4 | 119 | 64 | 53.8 | 671 | 5.6 | 4 | 5 | 103.84 | 29.8 | 167.8 |
| 2 | Syracuse | 5 | 152 | 88 | 57.9 | 1016 | 6.7 | 7 | 2 | 126.62 | 30.4 | 203.2 |
| 3 | Virginia Tech | 4 | 123 | 68 | 55.3 | 843 | 6.9 | 8 | 3 | 129.44 | 30.8 | 210.8 |
| 4 | Clemson | 4 | 138 | 79 | 57.2 | 980 | 7.1 | 5 | 3 | 124.51 | 34.5 | 245.0 |
| 5 | Virginia | 4 | 155 | 94 | 60.6 | 1134 | 7.3 | 7 | 3 | 133.13 | 38.8 | 283.5 |
| 6 | North Carolina State | 4 | 145 | 83 | 57.2 | 1079 | 7.4 | 9 | 4 | 134.70 | 36.3 | 269.8 |
| 7 | Louisville | 4 | 169 | 105 | 62.1 | 1269 | 7.5 | 10 | 5 | 138.82 | 42.3 | 317.3 |
| 8 | Boston College | 4 | 83 | 43 | 51.8 | 630 | 7.6 | 3 | 2 | 122.68 | 20.8 | 157.5 |
| 8 | North Carolina | 4 | 108 | 66 | 61.1 | 823 | 7.6 | 7 | 4 | 139.10 | 27.0 | 205.8 |
| 10 | Pittsburgh | 4 | 139 | 82 | 59.0 | 1070 | 7.7 | 6 | 6 | 129.27 | 34.8 | 267.5 |
| 11 | Miami (Florida) | 3 | 124 | 80 | 64.5 | 983 | 7.9 | 7 | 3 | 144.90 | 41.3 | 327.7 |
| 12 | Wake Forest | 4 | 91 | 56 | 61.5 | 803 | 8.8 | 7 | 1 | 158.84 | 22.8 | 200.8 |
| 13 | Duke | 4 | 144 | 80 | 55.6 | 1393 | 9.7 | 11 | 2 | 159.25 | 36.0 | 348.3 |
| 14 | Georgia Tech | 4 | 134 | 90 | 67.2 | 1341 | 10.0 | 12 | 1 | 179.28 | 33.5 | 335.3 |