2021 Atlantic Coast Conference Leaders Rushing Defense - Games in October Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Louisville | 4 | 129 | 381 | 2.95 | 4 | 32.25 | 95.25 |
| 2 | Pittsburgh | 4 | 118 | 391 | 3.31 | 5 | 29.50 | 97.75 |
| 3 | Miami (Florida) | 3 | 93 | 407 | 4.38 | 6 | 31.00 | 135.67 |
| 4 | Clemson | 4 | 141 | 438 | 3.11 | 2 | 35.25 | 109.50 |
| 5 | North Carolina State | 4 | 144 | 534 | 3.71 | 0 | 36.00 | 133.50 |
| 6 | Duke | 4 | 152 | 706 | 4.64 | 9 | 38.00 | 176.50 |
| 7 | Florida State | 4 | 147 | 768 | 5.22 | 6 | 36.75 | 192.00 |
| 8 | Syracuse | 5 | 195 | 789 | 4.05 | 8 | 39.00 | 157.80 |
| 9 | North Carolina | 4 | 156 | 821 | 5.26 | 8 | 39.00 | 205.25 |
| 10 | Georgia Tech | 4 | 186 | 855 | 4.60 | 5 | 46.50 | 213.75 |
| 11 | Virginia Tech | 4 | 162 | 885 | 5.46 | 8 | 40.50 | 221.25 |
| 12 | Boston College | 4 | 168 | 985 | 5.86 | 7 | 42.00 | 246.25 |
| 13 | Virginia | 4 | 149 | 998 | 6.70 | 10 | 37.25 | 249.50 |
| 14 | Wake Forest | 4 | 209 | 1138 | 5.44 | 11 | 52.25 | 284.50 |