2021 Atlantic Coast Conference Leaders Rushing Defense - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 4 | 120 | 336 | 2.80 | 4 | 30.00 | 84.00 |
| 2 | Boston College | 3 | 128 | 538 | 4.20 | 3 | 42.67 | 179.33 |
| 3 | Clemson | 6 | 197 | 576 | 2.92 | 2 | 32.83 | 96.00 |
| 4 | Syracuse | 5 | 179 | 581 | 3.25 | 4 | 35.80 | 116.20 |
| 5 | Florida State | 5 | 196 | 607 | 3.10 | 5 | 39.20 | 121.40 |
| 6 | Duke | 3 | 120 | 626 | 5.22 | 8 | 40.00 | 208.67 |
| 7 | Miami (Florida) | 5 | 163 | 646 | 3.96 | 5 | 32.60 | 129.20 |
| 8 | Pittsburgh | 6 | 215 | 662 | 3.08 | 10 | 35.83 | 110.33 |
| 9 | Virginia Tech | 5 | 181 | 714 | 3.94 | 9 | 36.20 | 142.80 |
| 10 | Wake Forest | 4 | 180 | 935 | 5.19 | 12 | 45.00 | 233.75 |
| 11 | Georgia Tech | 6 | 230 | 1098 | 4.77 | 11 | 38.33 | 183.00 |
| 12 | Virginia | 5 | 207 | 1175 | 5.68 | 12 | 41.40 | 235.00 |
| 13 | Louisville | 7 | 279 | 1265 | 4.53 | 17 | 39.86 | 180.71 |
| 14 | North Carolina | 7 | 271 | 1351 | 4.99 | 13 | 38.71 | 193.00 |