2021 Atlantic Coast Conference Leaders Rushing Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 2 | 67 | 219 | 3.27 | 4 | 33.50 | 109.50 |
| 2 | Pittsburgh | 3 | 105 | 302 | 2.88 | 3 | 35.00 | 100.67 |
| 3 | Virginia Tech | 2 | 87 | 388 | 4.46 | 4 | 43.50 | 194.00 |
| 4 | Syracuse | 4 | 138 | 431 | 3.12 | 4 | 34.50 | 107.75 |
| 5 | Clemson | 4 | 156 | 467 | 2.99 | 2 | 39.00 | 116.75 |
| 6 | Duke | 2 | 84 | 486 | 5.79 | 6 | 42.00 | 243.00 |
| 7 | Miami (Florida) | 4 | 124 | 519 | 4.19 | 4 | 31.00 | 129.75 |
| 7 | Wake Forest | 3 | 110 | 519 | 4.72 | 7 | 36.67 | 173.00 |
| 9 | Boston College | 3 | 128 | 538 | 4.20 | 3 | 42.67 | 179.33 |
| 10 | Florida State | 4 | 173 | 564 | 3.26 | 5 | 43.25 | 141.00 |
| 11 | North Carolina | 4 | 141 | 721 | 5.11 | 6 | 35.25 | 180.25 |
| 12 | Georgia Tech | 4 | 146 | 759 | 5.20 | 9 | 36.50 | 189.75 |
| 13 | Louisville | 5 | 194 | 896 | 4.62 | 14 | 38.80 | 179.20 |
| 14 | Virginia | 4 | 167 | 1006 | 6.02 | 9 | 41.75 | 251.50 |