2021 Atlantic Coast Conference Leaders Rushing Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 5 | 132 | 312 | 2.36 | 0 | 26.40 | 62.40 |
| 2 | Syracuse | 4 | 147 | 341 | 2.32 | 2 | 36.75 | 85.25 |
| 3 | North Carolina State | 4 | 114 | 357 | 3.13 | 0 | 28.50 | 89.25 |
| 4 | Boston College | 4 | 124 | 392 | 3.16 | 4 | 31.00 | 98.00 |
| 5 | Florida State | 4 | 148 | 424 | 2.86 | 3 | 37.00 | 106.00 |
| 6 | Pittsburgh | 5 | 173 | 494 | 2.86 | 6 | 34.60 | 98.80 |
| 7 | Miami (Florida) | 4 | 144 | 496 | 3.44 | 3 | 36.00 | 124.00 |
| 8 | Duke | 4 | 160 | 723 | 4.52 | 6 | 40.00 | 180.75 |
| 9 | Georgia Tech | 4 | 149 | 739 | 4.96 | 7 | 37.25 | 184.75 |
| 10 | Virginia Tech | 5 | 176 | 792 | 4.50 | 7 | 35.20 | 158.40 |
| 11 | Wake Forest | 4 | 177 | 813 | 4.59 | 6 | 44.25 | 203.25 |
| 12 | Virginia | 4 | 148 | 844 | 5.70 | 8 | 37.00 | 211.00 |
| 13 | North Carolina | 4 | 183 | 978 | 5.34 | 9 | 45.75 | 244.50 |
| 14 | Louisville | 5 | 197 | 1005 | 5.10 | 14 | 39.40 | 201.00 |