2021 Atlantic Coast Conference Leaders Rushing Defense - Games in December/January Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 1 | 21 | 66 | 3.14 | 0 | 21.00 | 66.00 |
| 2 | Pittsburgh | 2 | 75 | 138 | 1.84 | 1 | 37.50 | 69.00 |
| 3 | Louisville | 1 | 51 | 157 | 3.08 | 2 | 51.00 | 157.00 |
| 3 | North Carolina | 1 | 51 | 301 | 5.90 | 2 | 51.00 | 301.00 |
| 5 | Virginia Tech | 1 | 28 | 206 | 7.36 | 3 | 28.00 | 206.00 |
| 6 | Wake Forest | 2 | 67 | 223 | 3.33 | 4 | 33.50 | 111.50 |