2021 Atlantic Coast Conference Leaders Rushing Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 11 | 380 | 1170 | 3.08 | 7 | 34.55 | 106.36 |
| 2 | North Carolina State | 9 | 292 | 1144 | 3.92 | 9 | 32.44 | 127.11 |
| 3 | Pittsburgh | 11 | 368 | 947 | 2.57 | 11 | 33.45 | 86.09 |
| 3 | Syracuse | 9 | 333 | 1222 | 3.67 | 11 | 37.00 | 135.78 |
| 5 | Florida State | 9 | 375 | 1450 | 3.87 | 13 | 41.67 | 161.11 |
| 6 | Georgia Tech | 9 | 373 | 1653 | 4.43 | 14 | 41.44 | 183.67 |
| 6 | Boston College | 9 | 350 | 1739 | 4.97 | 14 | 38.89 | 193.22 |
| 6 | Virginia | 9 | 347 | 1982 | 5.71 | 14 | 38.56 | 220.22 |
| 9 | Miami (Florida) | 10 | 364 | 1512 | 4.15 | 15 | 36.40 | 151.20 |
| 10 | North Carolina | 10 | 372 | 1663 | 4.47 | 16 | 37.20 | 166.30 |
| 11 | Virginia Tech | 10 | 366 | 1792 | 4.90 | 17 | 36.60 | 179.20 |
| 12 | Louisville | 10 | 360 | 1582 | 4.39 | 20 | 36.00 | 158.20 |
| 12 | Wake Forest | 11 | 415 | 2036 | 4.91 | 20 | 37.73 | 185.09 |
| 14 | Duke | 10 | 380 | 2111 | 5.56 | 23 | 38.00 | 211.10 |