2021 Atlantic Coast Conference Leaders Long All Purpose Plays - Games in August/September Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Jashaun Corbin | FSU | SO | RB | 4 | 3 | 2 | 2 | 2 | 2 | 1 | 0 |
| 1 | Travis Levy | BC | SR | RB | 4 | 2 | 2 | 2 | 2 | 1 | 1 | 1 |
| 3 | Jordan Addison | Pittsburgh | SO | WR | 4 | 4 | 4 | 1 | 1 | 0 | 0 | 0 |
| 3 | Jaylin Alderman | Louisville | FR | LB | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Damien Alford | Syracuse | FR | WR | 4 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Raheem Blackshear | Va Tech | JR | RB | 4 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Khafre Brown | N Carolina | SO | WR | 4 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Ty Chandler | N Carolina | SR | RB | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Fentrell Cypress II | Virginia | SO | DB | 5 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Jordan Domineck | Ga Tech | SO | DL | 4 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Ja’Khi Douglas | FSU | FR | RB | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Justice Ellison | Wk Forest | FR | RB | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Pat Garwo III | BC | SO | RB | 4 | 4 | 2 | 1 | 1 | 0 | 0 | 0 |
| 3 | Cam'Ron Harris | Miami (Fl) | JR | RB | 5 | 3 | 3 | 3 | 1 | 1 | 1 | 0 |
| 3 | Sam Howell | N Carolina | JR | QB | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Ahmari Huggins-Bruce | Louisville | FR | WR | 4 | 2 | 2 | 1 | 1 | 1 | 1 | 1 |
| 3 | Jaquarii Roberson | Wk Forest | JR | WR | 4 | 3 | 2 | 1 | 1 | 0 | 0 | 0 |
| 3 | Tayvion Robinson | Va Tech | SO | WR | 4 | 2 | 2 | 2 | 1 | 0 | 0 | 0 |
| 3 | Emery Simmons | N Carolina | JR | WR | 4 | 4 | 2 | 1 | 1 | 0 | 0 | 0 |
| 3 | Brashard Smith | Miami (Fl) | FR | WR | 5 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Demick Starling | Virginia | SO | WR | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Ja'Sir Taylor | Wk Forest | SR | DB | 4 | 2 | 2 | 1 | 1 | 1 | 1 | 1 |
| 3 | Sean Tucker | Syracuse | FR | RB | 4 | 4 | 4 | 2 | 1 | 1 | 0 | 0 |
| 3 | Ontaria Wilson | FSU | JR | WR | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |