2021 Big 12 Conference Leaders Tackles For Loss - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Oklahoma State | 3 | 17.0 | 72 | 5.67 |
| 2 | Texas Tech | 2 | 15.0 | 66 | 7.50 |
| 3 | Baylor | 2 | 14.0 | 66 | 7.00 |
| 4 | Texas | 2 | 11.0 | 41 | 5.50 |
| 5 | Oklahoma | 1 | 9.0 | 37 | 9.00 |
| 6 | Iowa State | 1 | 8.0 | 26 | 8.00 |
| 7 | Kansas State | 1 | 6.0 | 26 | 6.00 |
| 8 | TCU | 1 | 4.0 | 8 | 4.00 |
| 9 | Kansas | 1 | 2.0 | 2 | 2.00 |