2021 Big 12 Conference Leaders Tackles For Loss - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Oklahoma State | 10 | 91.0 | 389 | 9.10 |
| 2 | Oklahoma | 11 | 80.0 | 315 | 7.27 |
| 3 | Baylor | 11 | 79.0 | 345 | 7.18 |
| 4 | Kansas State | 11 | 77.0 | 253 | 7.00 |
| 5 | West Virginia | 12 | 73.0 | 294 | 6.08 |
| 5 | Iowa State | 11 | 73.0 | 282 | 6.64 |
| 7 | Texas | 10 | 61.0 | 183 | 6.10 |
| 8 | Texas Tech | 10 | 42.0 | 159 | 4.20 |
| 9 | TCU | 10 | 38.0 | 157 | 3.80 |
| 10 | Kansas | 10 | 37.0 | 144 | 3.70 |