2021 Big 12 Conference Leaders Passes Defended - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Baylor | 10 | 13 | 32 | 45 | 4.50 |
| 2 | Oklahoma State | 10 | 7 | 31 | 38 | 3.80 |
| 3 | Texas Tech | 9 | 4 | 30 | 34 | 3.78 |
| 4 | Iowa State | 9 | 7 | 24 | 31 | 3.44 |
| 4 | Texas | 9 | 6 | 25 | 31 | 3.44 |
| 6 | Oklahoma | 9 | 8 | 21 | 29 | 3.22 |
| 6 | TCU | 9 | 6 | 23 | 29 | 3.22 |
| 8 | West Virginia | 9 | 8 | 19 | 27 | 3.00 |
| 9 | Kansas State | 9 | 5 | 18 | 23 | 2.56 |
| 10 | Kansas | 9 | 6 | 16 | 22 | 2.44 |