2021 Big 12 Conference Leaders Passes Defended - Games in August/September Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Texas Tech | 4 | 6 | 18 | 24 | 6.00 |
| 2 | Kansas State | 4 | 4 | 11 | 15 | 3.75 |
| 3 | Baylor | 4 | 4 | 10 | 14 | 3.50 |
| 4 | Oklahoma State | 4 | 2 | 11 | 13 | 3.25 |
| 4 | West Virginia | 4 | 1 | 12 | 13 | 3.25 |
| 6 | TCU | 3 | 4 | 4 | 8 | 2.67 |
| 7 | Kansas | 4 | 1 | 9 | 10 | 2.50 |
| 8 | Texas | 4 | 3 | 6 | 9 | 2.25 |
| 9 | Iowa State | 4 | 3 | 3 | 6 | 1.50 |
| 9 | Oklahoma | 4 | 3 | 3 | 6 | 1.50 |