2021 Big 12 Conference Leaders Passes Defended - Games in October Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Baylor | 4 | 5 | 15 | 20 | 5.00 |
| 2 | Iowa State | 4 | 4 | 11 | 15 | 3.75 |
| 2 | Texas | 4 | 4 | 11 | 15 | 3.75 |
| 4 | Oklahoma State | 4 | 5 | 8 | 13 | 3.25 |
| 4 | West Virginia | 4 | 3 | 10 | 13 | 3.25 |
| 6 | TCU | 5 | 3 | 13 | 16 | 3.20 |
| 7 | Oklahoma | 5 | 2 | 12 | 14 | 2.80 |
| 8 | Texas Tech | 5 | 1 | 12 | 13 | 2.60 |
| 9 | Kansas | 4 | 2 | 7 | 9 | 2.25 |
| 10 | Kansas State | 4 | 2 | 6 | 8 | 2.00 |