2021 Big 12 Conference Leaders Passing - Games vs. Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Caleb Williams | Oklahoma | FR | QB | 8 | 174 | 110 | 63.2 | 1586 | 9.1 | 18 | 4 | 169.33 | 21.8 | 198.3 |
| 2 | Brock Purdy | Iowa State | SR | QB | 9 | 291 | 214 | 73.5 | 2359 | 8.1 | 15 | 4 | 155.90 | 32.3 | 262.1 |
| 3 | Max Duggan | TCU | JR | QB | 7 | 149 | 98 | 65.8 | 1331 | 8.9 | 9 | 4 | 155.37 | 21.3 | 190.1 |
| 4 | Skylar Thompson | Kansas St | SR | QB | 7 | 187 | 129 | 69.0 | 1614 | 8.6 | 9 | 2 | 155.22 | 26.7 | 230.6 |
| 5 | Casey Thompson | Texas | JR | QB | 9 | 230 | 141 | 61.3 | 1851 | 8.0 | 21 | 8 | 152.07 | 25.6 | 205.7 |
| 6 | Gerry Bohanon | Baylor | JR | QB | 8 | 184 | 116 | 63.0 | 1528 | 8.3 | 13 | 5 | 150.67 | 23.0 | 191.0 |
| 7 | Jarret Doege | WVU | SR | QB | 9 | 298 | 201 | 67.4 | 2179 | 7.3 | 13 | 8 | 137.89 | 33.1 | 242.1 |
| 8 | Spencer Sanders | Okla St | JR | QB | 10 | 302 | 188 | 62.3 | 2213 | 7.3 | 14 | 11 | 131.83 | 30.2 | 221.3 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 15.0 pass attempts per game played.