2021 Big 12 Conference Leaders Total Offense - Games in December/January Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Kennedy Brooks | Oklahoma | JR | RB | 1 | 142 | 0 | 14 | 142 | 10.14 | 142.0 |
| 2 | Donovan Smith | Texas Tech | FR | QB | 1 | 30 | 252 | 33 | 282 | 8.55 | 282.0 |
| 3 | Skylar Thompson | Kansas St | SR | QB | 1 | 10 | 259 | 33 | 269 | 8.15 | 269.0 |
| 4 | Caleb Williams | Oklahoma | FR | QB | 1 | 34 | 242 | 34 | 276 | 8.12 | 276.0 |
| 5 | Deuce Vaughn | Kansas St | SO | RB | 1 | 146 | 0 | 21 | 146 | 6.95 | 146.0 |
| 6 | Tahj Brooks | Texas Tech | SO | RB | 1 | 107 | 0 | 16 | 107 | 6.69 | 107.0 |
| 7 | Spencer Sanders | Okla St | JR | QB | 2 | 154 | 628 | 127 | 782 | 6.16 | 391.0 |
| 8 | SaRodorick Thompson | Texas Tech | JR | RB | 1 | 80 | 0 | 14 | 80 | 5.71 | 80.0 |
| 9 | Abram Smith | Baylor | SR | RB | 2 | 235 | 0 | 42 | 235 | 5.60 | 117.5 |
| 10 | Marcus Major | Oklahoma | SO | RB | 1 | 54 | 0 | 10 | 54 | 5.40 | 54.0 |
| 11 | Brock Purdy | Iowa State | SR | QB | 1 | 14 | 204 | 44 | 218 | 4.95 | 218.0 |
| 12 | Jaylen Warren | Okla St | SR | RB | 2 | 82 | 0 | 19 | 82 | 4.32 | 41.0 |
| 13 | Tony Mathis Jr. | WVU | SO | RB | 1 | 56 | 0 | 13 | 56 | 4.31 | 56.0 |
| 14 | Jarret Doege | WVU | SR | QB | 1 | -22 | 140 | 39 | 118 | 3.03 | 118.0 |
| 15 | Jirehl Brock | Iowa State | SO | RB | 1 | 42 | 0 | 14 | 42 | 3.00 | 42.0 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 9.0 plays per game played.