2021 Big 12 Conference Leaders Total Offense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Casey Thompson | Texas | JR | QB | 5 | 47 | 945 | 138 | 992 | 7.19 | 198.4 |
| 2 | Abram Smith | Baylor | SR | RB | 5 | 668 | 0 | 99 | 668 | 6.75 | 133.6 |
| 3 | Kennedy Brooks | Oklahoma | JR | RB | 3 | 336 | 0 | 50 | 336 | 6.72 | 112.0 |
| 4 | Spencer Sanders | Okla St | JR | QB | 4 | 323 | 1024 | 208 | 1347 | 6.48 | 336.8 |
| 5 | Caleb Williams | Oklahoma | FR | QB | 3 | 87 | 636 | 120 | 723 | 6.03 | 241.0 |
| 6 | Gerry Bohanon | Baylor | JR | QB | 4 | 150 | 561 | 121 | 711 | 5.88 | 177.8 |
| 7 | Donovan Smith | Texas Tech | FR | QB | 3 | 3 | 544 | 97 | 547 | 5.64 | 182.3 |
| 8 | Brock Purdy | Iowa State | SR | QB | 5 | -27 | 1193 | 211 | 1166 | 5.53 | 233.2 |
| 9 | Jason Bean | Kansas | JR | QB | 3 | 145 | 313 | 85 | 458 | 5.39 | 152.7 |
| 10 | Tahj Brooks | Texas Tech | SO | RB | 4 | 198 | 0 | 38 | 198 | 5.21 | 49.5 |
| 11 | Emari Demercado | TCU | SR | RB | 3 | 206 | 0 | 40 | 206 | 5.15 | 68.7 |
| 11 | Deuce Vaughn | Kansas St | SO | RB | 3 | 201 | 0 | 39 | 201 | 5.15 | 67.0 |
| 13 | Bijan Robinson | Texas | SO | RB | 5 | 487 | 0 | 97 | 487 | 5.02 | 97.4 |
| 14 | Breece Hall | Iowa State | JR | RB | 4 | 387 | 0 | 83 | 387 | 4.66 | 96.8 |
| 15 | Jarret Doege | WVU | SR | QB | 3 | -50 | 506 | 107 | 456 | 4.26 | 152.0 |
| 16 | Garrett Greene | WVU | FR | QB | 3 | 73 | 61 | 33 | 134 | 4.06 | 44.7 |
| 17 | Devin Neal | Kansas | FR | RB | 3 | 158 | 0 | 42 | 158 | 3.76 | 52.7 |
| 18 | Jaylen Warren | Okla St | SR | RB | 4 | 263 | 0 | 72 | 263 | 3.65 | 65.8 |
| 19 | Leddie Brown | WVU | SR | RB | 3 | 124 | 0 | 37 | 124 | 3.35 | 41.3 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 9.0 plays per game played.