2021 Big 12 Conference Leaders Total Offense - Games at Home Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Gerry Bohanon | Baylor | JR | QB | 6 | 213 | 1274 | 188 | 1487 | 7.91 | 247.8 |
| 2 | Casey Thompson | Texas | JR | QB | 6 | 71 | 1215 | 166 | 1286 | 7.75 | 214.3 |
| 3 | Spencer Sanders | Okla St | JR | QB | 6 | 355 | 1305 | 221 | 1660 | 7.51 | 276.7 |
| 4 | Max Duggan | TCU | JR | QB | 6 | 244 | 1309 | 216 | 1553 | 7.19 | 258.8 |
| 5 | Skylar Thompson | Kansas St | SR | QB | 6 | -14 | 1160 | 160 | 1146 | 7.16 | 191.0 |
| 6 | Brock Purdy | Iowa State | SR | QB | 6 | 122 | 1403 | 214 | 1525 | 7.13 | 254.2 |
| 7 | Spencer Rattler | Oklahoma | SO | QB | 6 | 71 | 1093 | 168 | 1164 | 6.93 | 194.0 |
| 8 | Jarret Doege | WVU | SR | QB | 6 | -54 | 1539 | 220 | 1485 | 6.75 | 247.5 |
| 9 | Roschon Johnson | Texas | JR | RB | 6 | 425 | 2 | 64 | 427 | 6.67 | 71.2 |
| 10 | Bijan Robinson | Texas | SO | RB | 5 | 572 | 0 | 86 | 572 | 6.65 | 114.4 |
| 11 | Abram Smith | Baylor | SR | RB | 7 | 858 | 0 | 131 | 858 | 6.55 | 122.6 |
| 12 | Kennedy Brooks | Oklahoma | JR | RB | 7 | 530 | 0 | 84 | 530 | 6.31 | 75.7 |
| 13 | Breece Hall | Iowa State | JR | RB | 6 | 709 | 0 | 114 | 709 | 6.22 | 118.2 |
| 14 | Trestan Ebner | Baylor | SR | RB | 7 | 449 | 0 | 74 | 449 | 6.07 | 64.1 |
| 15 | Jason Bean | Kansas | JR | QB | 6 | 202 | 610 | 145 | 812 | 5.60 | 135.3 |
| 16 | Deuce Vaughn | Kansas St | SO | RB | 7 | 755 | 0 | 138 | 755 | 5.47 | 107.9 |
| 17 | Donovan Smith | Texas Tech | FR | QB | 5 | 50 | 405 | 90 | 455 | 5.06 | 91.0 |
| 18 | Leddie Brown | WVU | SR | RB | 6 | 540 | 0 | 116 | 540 | 4.66 | 90.0 |
| 19 | SaRodorick Thompson | Texas Tech | JR | RB | 5 | 205 | 0 | 46 | 205 | 4.46 | 41.0 |
| 20 | Jaylen Warren | Okla St | SR | RB | 7 | 532 | 0 | 126 | 532 | 4.22 | 76.0 |
| 21 | Devin Neal | Kansas | FR | RB | 5 | 250 | 0 | 68 | 250 | 3.68 | 50.0 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 9.0 plays per game played.