2021 Big 12 Conference Leaders Long All Purpose Plays - Games vs. Conference Teams Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Breece Hall | Iowa State | JR | RB | 9 | 13 | 7 | 4 | 3 | 3 | 1 | 0 |
| 2 | Derius Davis | TCU | SR | WR | 9 | 9 | 6 | 3 | 3 | 2 | 1 | 1 |
| 2 | Malik Knowles | Kansas St | JR | WR | 9 | 9 | 6 | 4 | 4 | 2 | 2 | 2 |
| 4 | Taye Barber | TCU | SR | WR | 9 | 2 | 2 | 2 | 1 | 1 | 0 | 0 |
| 4 | Nik Bonitto | Oklahoma | JR | OLB | 9 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 4 | Trestan Ebner | Baylor | SR | RB | 10 | 8 | 4 | 3 | 2 | 1 | 1 | 1 |
| 4 | Kaylon Geiger Sr. | Texas Tech | SR | WR | 9 | 5 | 3 | 2 | 1 | 1 | 0 | 0 |
| 4 | Will Howard | Kansas St | SO | QB | 3 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 4 | Daniel Imatorbhebhe | Kansas St | SR | TE | 8 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 4 | Quentin Johnston | TCU | SO | WR | 6 | 5 | 3 | 2 | 1 | 1 | 0 | 0 |
| 4 | Travis Koontz | Texas Tech | SR | TE | 8 | 2 | 2 | 1 | 1 | 1 | 0 | 0 |
| 4 | Kendre Miller | TCU | SO | RB | 7 | 6 | 5 | 4 | 2 | 1 | 0 | 0 |
| 4 | Brennan Presley | Okla St | SO | WR | 10 | 6 | 3 | 1 | 1 | 1 | 1 | 1 |
| 4 | Abram Smith | Baylor | SR | RB | 10 | 6 | 3 | 2 | 1 | 1 | 0 | 0 |
| 4 | JD Spielman | TCU | SR | WR | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 4 | Jason Taylor II | Okla St | JR | S | 10 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 4 | SaRodorick Thompson | Texas Tech | JR | RB | 9 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 4 | Tyquan Thornton | Baylor | SR | WR | 10 | 5 | 5 | 1 | 1 | 1 | 0 | 0 |
| 4 | Deuce Vaughn | Kansas St | SO | RB | 9 | 8 | 5 | 3 | 2 | 1 | 1 | 0 |
| 4 | Caleb Williams | Oklahoma | FR | QB | 8 | 5 | 5 | 3 | 2 | 1 | 0 | 0 |
| 4 | Xavier Worthy | Texas | FR | WR | 9 | 8 | 5 | 4 | 3 | 1 | 0 | 0 |