2021 Big 12 Conference Leaders Passing - Games vs. Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Casey Thompson | Texas | JR | QB | 9 | 230 | 141 | 61.3 | 1851 | 8.0 | 21 | 8 | 152.07 | 25.6 | 205.7 |
| 2 | Caleb Williams | Oklahoma | FR | QB | 8 | 174 | 110 | 63.2 | 1586 | 9.1 | 18 | 4 | 169.33 | 21.8 | 198.3 |
| 3 | Brock Purdy | Iowa State | SR | QB | 9 | 291 | 214 | 73.5 | 2359 | 8.1 | 15 | 4 | 155.90 | 32.3 | 262.1 |
| 4 | Spencer Sanders | Okla St | JR | QB | 10 | 302 | 188 | 62.3 | 2213 | 7.3 | 14 | 11 | 131.83 | 30.2 | 221.3 |
| 5 | Jarret Doege | WVU | SR | QB | 9 | 298 | 201 | 67.4 | 2179 | 7.3 | 13 | 8 | 137.89 | 33.1 | 242.1 |
| 5 | Gerry Bohanon | Baylor | JR | QB | 8 | 184 | 116 | 63.0 | 1528 | 8.3 | 13 | 5 | 150.67 | 23.0 | 191.0 |
| 7 | Skylar Thompson | Kansas St | SR | QB | 7 | 187 | 129 | 69.0 | 1614 | 8.6 | 9 | 2 | 155.22 | 26.7 | 230.6 |
| 7 | Max Duggan | TCU | JR | QB | 7 | 149 | 98 | 65.8 | 1331 | 8.9 | 9 | 4 | 155.37 | 21.3 | 190.1 |
| 9 | Jalon Daniels | Kansas | SO | QB | 5 | 112 | 78 | 69.6 | 811 | 7.2 | 7 | 3 | 145.73 | 22.4 | 162.2 |
| 10 | Donovan Smith | Texas Tech | FR | QB | 9 | 112 | 71 | 63.4 | 936 | 8.4 | 6 | 2 | 147.70 | 12.4 | 104.0 |
| 11 | Henry Colombi | Texas Tech | SR | QB | 6 | 148 | 95 | 64.2 | 1283 | 8.7 | 5 | 5 | 141.40 | 24.7 | 213.8 |
| 11 | Blake Shapen | Baylor | FR | QB | 5 | 85 | 61 | 71.8 | 589 | 6.9 | 5 | 0 | 149.38 | 17.0 | 117.8 |
| 13 | Spencer Rattler | Oklahoma | SO | QB | 6 | 88 | 66 | 75.0 | 722 | 8.2 | 4 | 3 | 152.10 | 14.7 | 120.3 |
| 14 | Hudson Card | Texas | FR | QB | 5 | 44 | 27 | 61.4 | 276 | 6.3 | 3 | 1 | 132.00 | 8.8 | 55.2 |
| 15 | Chandler Morris | TCU | FR | QB | 3 | 75 | 49 | 65.3 | 697 | 9.3 | 2 | 0 | 152.19 | 25.0 | 232.3 |
| 15 | Jason Bean | Kansas | JR | QB | 8 | 100 | 54 | 54.0 | 577 | 5.8 | 2 | 4 | 101.07 | 12.5 | 72.1 |
| 15 | Shane Illingworth | Okla St | SO | QB | 2 | 10 | 6 | 60.0 | 70 | 7.0 | 2 | 0 | 184.80 | 5.0 | 35.0 |
| 15 | Miles Kendrick | Kansas | SR | QB | 5 | 18 | 12 | 66.7 | 106 | 5.9 | 2 | 1 | 141.70 | 3.6 | 21.2 |
| 19 | Jaren Lewis | Kansas St | SO | QB | 3 | 20 | 10 | 50.0 | 148 | 7.4 | 1 | 2 | 108.66 | 6.7 | 49.3 |
| 19 | Hunter Dekkers | Iowa State | FR | QB | 2 | 14 | 7 | 50.0 | 58 | 4.1 | 1 | 1 | 94.08 | 7.0 | 29.0 |
| 19 | Xavier Hutchinson | Iowa State | SR | WR | 9 | 1 | 1 | 100.0 | 49 | 49.0 | 1 | 0 | 841.60 | 0.1 | 5.4 |
| 19 | Tyquan Thornton | Baylor | SR | WR | 10 | 1 | 1 | 100.0 | 6 | 6.0 | 1 | 0 | 480.40 | 0.1 | 0.6 |