2021 Big 12 Conference Leaders Passing - From Opponent's 39 to 21 Yard Line through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | TD | Int | Rating | Long | 1st | 15+ | 25+ | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brock Purdy | Iowa State | SR | QB | 13 | 80 | 57 | 71.3 | 645 | 4 | 3 | 147.98 | 36 | 30 | 15 | 7 |
| 2 | Spencer Sanders | Okla St | JR | QB | 13 | 69 | 50 | 72.5 | 640 | 5 | 1 | 171.38 | 36 | 30 | 17 | 9 |
| 3 | Jarret Doege | WVU | SR | QB | 13 | 69 | 46 | 66.7 | 535 | 4 | 1 | 148.03 | 39 | 24 | 14 | 6 |
| 4 | Skylar Thompson | Kansas St | SR | QB | 10 | 54 | 39 | 72.2 | 458 | 2 | 2 | 148.27 | 37 | 21 | 13 | 5 |
| 5 | Casey Thompson | Texas | JR | QB | 11 | 52 | 32 | 61.5 | 471 | 7 | 4 | 166.67 | 38 | 19 | 13 | 8 |
| 5 | Gerry Bohanon | Baylor | JR | QB | 12 | 50 | 32 | 64.0 | 393 | 4 | 3 | 144.42 | 33 | 18 | 11 | 2 |
| 7 | Spencer Rattler | Oklahoma | SO | QB | 6 | 32 | 22 | 68.8 | 234 | 0 | 0 | 130.18 | 22 | 11 | 6 | 0 |
| 8 | Caleb Williams | Oklahoma | FR | QB | 10 | 31 | 19 | 61.3 | 240 | 2 | 0 | 147.61 | 29 | 14 | 8 | 1 |
| 9 | Max Duggan | TCU | JR | QB | 8 | 31 | 18 | 58.1 | 225 | 3 | 2 | 138.07 | 30 | 12 | 5 | 2 |
| 10 | Jalon Daniels | Kansas | SO | QB | 5 | 24 | 17 | 70.8 | 151 | 1 | 0 | 137.43 | 28 | 8 | 4 | 1 |
| 11 | Donovan Smith | Texas Tech | FR | QB | 6 | 25 | 15 | 60.0 | 177 | 2 | 0 | 145.87 | 39 | 7 | 3 | 2 |
| 11 | Henry Colombi | Texas Tech | SR | QB | 5 | 27 | 15 | 55.6 | 140 | 0 | 0 | 99.11 | 25 | 7 | 3 | 1 |
| 13 | Blake Shapen | Baylor | FR | QB | 4 | 17 | 10 | 58.8 | 117 | 0 | 0 | 116.63 | 31 | 5 | 3 | 1 |
| 14 | Jason Bean | Kansas | JR | QB | 7 | 19 | 9 | 47.4 | 85 | 0 | 0 | 84.95 | 20 | 4 | 2 | 0 |
| 15 | Tyler Shough | Texas Tech | JR | QB | 2 | 8 | 7 | 87.5 | 98 | 2 | 0 | 272.90 | 28 | 5 | 3 | 2 |
| 16 | Hunter Dekkers | Iowa State | FR | QB | 3 | 10 | 6 | 60.0 | 56 | 0 | 0 | 107.04 | 22 | 4 | 3 | 0 |
| 17 | Hudson Card | Texas | FR | QB | 5 | 11 | 5 | 45.5 | 79 | 1 | 0 | 135.79 | 33 | 3 | 2 | 1 |
| 17 | Chandler Morris | TCU | FR | QB | 3 | 11 | 5 | 45.5 | 43 | 0 | 0 | 78.30 | 17 | 2 | 1 | 0 |
| 17 | Will Howard | Kansas St | SO | QB | 3 | 7 | 5 | 71.4 | 33 | 0 | 0 | 111.03 | 11 | 2 | 0 | 0 |
| 20 | Shane Illingworth | Okla St | SO | QB | 2 | 9 | 3 | 33.3 | 36 | 0 | 1 | 44.71 | 19 | 2 | 1 | 0 |
| 20 | Garrett Greene | WVU | FR | QB | 4 | 6 | 3 | 50.0 | 17 | 0 | 0 | 73.80 | 16 | 1 | 1 | 0 |
| 22 | Will Crowder | WVU | FR | QB | 1 | 2 | 2 | 100.0 | 28 | 0 | 0 | 217.60 | 20 | 1 | 1 | 0 |
| 22 | Matthew Downing | TCU | JR | QB | 1 | 2 | 2 | 100.0 | 21 | 0 | 0 | 188.20 | 12 | 1 | 0 | 0 |
| 22 | Miles Kendrick | Kansas | SR | QB | 2 | 5 | 2 | 40.0 | 10 | 0 | 0 | 56.80 | 12 | 1 | 0 | 0 |
| 25 | Ralph Rucker | Oklahoma | FR | QB | 1 | 1 | 1 | 100.0 | 12 | 0 | 0 | 200.80 | 12 | 1 | 0 | 0 |
| 25 | Taye Barber | TCU | SR | WR | 1 | 1 | 1 | 100.0 | 7 | 0 | 0 | 158.80 | 7 | 0 | 0 | 0 |
| 25 | Brennan Presley | Okla St | SO | WR | 1 | 1 | 1 | 100.0 | 6 | 0 | 0 | 150.40 | 6 | 1 | 0 | 0 |
| 25 | Roschon Johnson | Texas | JR | RB | 1 | 1 | 1 | 100.0 | 2 | 0 | 0 | 116.80 | 2 | 0 | 0 | 0 |
| 29 | Jacob Zeno | Baylor | SO | QB | 1 | 1 | 0 | 0.0 | 0 | 0 | 0 | 0.00 | 0 | 0 | 0 | 0 |
| 29 | Ethan Bullock | Okla St | SR | QB | 1 | 1 | 0 | 0.0 | 0 | 0 | 0 | 0.00 | 0 | 0 | 0 | 0 |
| 29 | Jaren Lewis | Kansas St | SO | QB | 3 | 4 | 0 | 0.0 | 0 | 0 | 2 | -100.00 | 0 | 0 | 0 | 0 |
| 1st: First Downs; 15+: Pass completions of 15 or more yards; 25+: Pass completions of 25 or more yards | ||||||||||||||||