2021 Big 12 Conference Leaders Passing - Games in August/September Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Spencer Rattler | Oklahoma | SO | QB | 4 | 135 | 100 | 74.1 | 1017 | 7.5 | 8 | 3 | 152.47 | 33.8 | 254.3 |
| 2 | Max Duggan | TCU | JR | QB | 3 | 78 | 47 | 60.3 | 717 | 9.2 | 7 | 2 | 161.95 | 26.0 | 239.0 |
| 3 | Jarret Doege | WVU | SR | QB | 4 | 117 | 73 | 62.4 | 889 | 7.6 | 6 | 4 | 136.29 | 29.3 | 222.3 |
| 4 | Brock Purdy | Iowa State | SR | QB | 4 | 110 | 77 | 70.0 | 888 | 8.1 | 4 | 4 | 142.54 | 27.5 | 222.0 |
| 5 | Tyler Shough | Texas Tech | JR | QB | 4 | 92 | 64 | 69.6 | 872 | 9.5 | 6 | 3 | 164.19 | 23.0 | 218.0 |
| 6 | Gerry Bohanon | Baylor | JR | QB | 4 | 89 | 65 | 73.0 | 817 | 9.2 | 7 | 0 | 176.09 | 22.3 | 204.3 |
| 7 | Spencer Sanders | Okla St | JR | QB | 3 | 73 | 43 | 58.9 | 591 | 8.1 | 4 | 1 | 142.25 | 24.3 | 197.0 |
| 8 | Jason Bean | Kansas | JR | QB | 4 | 99 | 56 | 56.6 | 732 | 7.4 | 5 | 2 | 131.31 | 24.8 | 183.0 |
| 9 | Casey Thompson | Texas | JR | QB | 4 | 54 | 42 | 77.8 | 565 | 10.5 | 8 | 2 | 207.15 | 13.5 | 141.3 |
| 10 | Will Howard | Kansas St | SO | QB | 3 | 39 | 19 | 48.7 | 249 | 6.4 | 1 | 1 | 105.68 | 13.0 | 83.0 |
| 11 | Hudson Card | Texas | FR | QB | 4 | 39 | 24 | 61.5 | 314 | 8.1 | 2 | 0 | 146.09 | 9.8 | 78.5 |
| 12 | Garrett Greene | WVU | FR | QB | 3 | 12 | 7 | 58.3 | 76 | 6.3 | 0 | 0 | 111.53 | 4.0 | 25.3 |
| 13 | Mario Williams | Oklahoma | FR | WR | 4 | 1 | 1 | 100.0 | 10 | 10.0 | 0 | 0 | 184.00 | 0.3 | 2.5 |
Note: To qualify, player must have played in 75% of his team's games.