2021 Conference USA Leaders First Downs - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 2 | 15 | 37 | 3 | 55 | 27.5 |
| 2 | Louisiana Tech | 2 | 11 | 24 | 5 | 40 | 20.0 |
| 3 | Charlotte | 2 | 12 | 22 | 3 | 37 | 18.5 |
| 4 | Rice | 2 | 9 | 18 | 6 | 33 | 16.5 |
| 5 | UTSA | 1 | 10 | 14 | 2 | 26 | 26.0 |
| 6 | Florida Atlantic | 1 | 5 | 13 | 5 | 23 | 23.0 |
| 7 | North Texas | 1 | 12 | 8 | 1 | 21 | 21.0 |
| 8 | Middle Tennessee | 1 | 9 | 11 | 0 | 20 | 20.0 |
| 9 | Old Dominion | 1 | 8 | 9 | 0 | 17 | 17.0 |
| 10 | UAB | 1 | 8 | 1 | 2 | 11 | 11.0 |
| 10 | Southern Mississippi | 1 | 3 | 7 | 1 | 11 | 11.0 |
| 12 | Florida International | 1 | 2 | 6 | 2 | 10 | 10.0 |