2021 Conference USA Leaders First Downs - Games Won Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | UTSA | 12 | 120 | 139 | 25 | 284 | 23.7 |
| 2 | Western Kentucky | 9 | 65 | 162 | 21 | 248 | 27.6 |
| 3 | Marshall | 7 | 80 | 93 | 10 | 183 | 26.1 |
| 4 | UAB | 9 | 82 | 81 | 11 | 174 | 19.3 |
| 5 | North Texas | 6 | 93 | 47 | 8 | 148 | 24.7 |
| 6 | Middle Tennessee State | 7 | 61 | 71 | 14 | 146 | 20.9 |
| 7 | Old Dominion | 6 | 65 | 59 | 11 | 135 | 22.5 |
| 8 | UTEP | 7 | 54 | 64 | 13 | 131 | 18.7 |
| 9 | Florida Atlantic | 5 | 57 | 52 | 8 | 117 | 23.4 |
| 9 | Charlotte | 5 | 44 | 62 | 11 | 117 | 23.4 |
| 11 | Rice | 4 | 34 | 42 | 8 | 84 | 21.0 |
| 12 | Louisiana Tech | 3 | 24 | 42 | 6 | 72 | 24.0 |
| 13 | Southern Miss | 3 | 38 | 16 | 3 | 57 | 19.0 |
| 14 | FIU | 1 | 10 | 12 | 0 | 22 | 22.0 |