2021 Conference USA Leaders First Downs - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | UAB | 2 | 20 | 12 | 2 | 34 | 17.0 |
| 1 | Rice | 2 | 7 | 18 | 9 | 34 | 17.0 |
| 3 | Western Kentucky | 1 | 6 | 22 | 3 | 31 | 31.0 |
| 4 | Louisiana Tech | 1 | 9 | 14 | 3 | 26 | 26.0 |
| 5 | UTSA | 1 | 6 | 9 | 6 | 21 | 21.0 |
| 6 | Old Dominion | 1 | 8 | 9 | 0 | 17 | 17.0 |
| 7 | Marshall | 1 | 8 | 5 | 0 | 13 | 13.0 |
| 8 | Southern Mississippi | 1 | 3 | 7 | 1 | 11 | 11.0 |