2021 Conference USA Leaders Sacks - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | UAB | 8 | 30.0 | 204 | 3.75 |
| 2 | Western Kentucky | 9 | 27.0 | 160 | 3.00 |
| 3 | North Texas | 8 | 23.0 | 160 | 2.88 |
| 4 | Middle Tennessee | 8 | 22.0 | 175 | 2.75 |
| 5 | UTSA | 9 | 24.0 | 200 | 2.67 |
| 6 | Rice | 8 | 20.0 | 145 | 2.50 |
| 6 | Marshall | 8 | 20.0 | 130 | 2.50 |
| 8 | UTEP | 8 | 16.0 | 114 | 2.00 |
| 8 | Old Dominion | 8 | 16.0 | 101 | 2.00 |
| 10 | Florida Atlantic | 8 | 14.0 | 110 | 1.75 |
| 11 | Louisiana Tech | 8 | 13.0 | 92 | 1.63 |
| 12 | Southern Mississippi | 8 | 12.0 | 84 | 1.50 |
| 13 | Charlotte | 8 | 10.0 | 70 | 1.25 |
| 14 | Florida International | 8 | 7.0 | 34 | 0.88 |