2021 Conference USA Leaders Sacks - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Rice | 2 | 5.0 | 39 | 2.50 |
| 2 | Marshall | 1 | 2.0 | 12 | 2.00 |
| 2 | Old Dominion | 1 | 2.0 | 11 | 2.00 |
| 2 | Southern Mississippi | 1 | 2.0 | 11 | 2.00 |
| 5 | Louisiana Tech | 1 | 1.0 | 7 | 1.00 |
| 5 | UTSA | 1 | 1.0 | 6 | 1.00 |
| 7 | UAB | 2 | 1.0 | 5 | 0.50 |