2021 Conference USA Leaders Sacks - Games at Home Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Middle Tennessee | 5 | 19.0 | 149 | 3.80 |
| 2 | UAB | 5 | 18.0 | 105 | 3.60 |
| 3 | North Texas | 6 | 21.0 | 147 | 3.50 |
| 4 | UTSA | 7 | 22.0 | 175 | 3.14 |
| 5 | Marshall | 6 | 18.0 | 112 | 3.00 |
| 6 | Rice | 6 | 15.0 | 113 | 2.50 |
| 7 | Southern Mississippi | 6 | 12.0 | 93 | 2.00 |
| 8 | Florida Atlantic | 6 | 11.0 | 97 | 1.83 |
| 8 | Western Kentucky | 6 | 11.0 | 84 | 1.83 |
| 8 | Florida International | 6 | 11.0 | 50 | 1.83 |
| 11 | UTEP | 6 | 10.0 | 60 | 1.67 |
| 12 | Old Dominion | 6 | 9.0 | 66 | 1.50 |
| 13 | Louisiana Tech | 6 | 8.0 | 52 | 1.33 |
| 13 | Charlotte | 6 | 8.0 | 45 | 1.33 |