2021 Conference USA Leaders Rushing Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Louisiana Tech | 2 | 50 | 232 | 4.64 | 4 | 25.00 | 116.00 |
| 2 | UTSA | 1 | 35 | 150 | 4.29 | 0 | 35.00 | 150.00 |
| 3 | Western Kentucky | 2 | 82 | 326 | 3.98 | 7 | 41.00 | 163.00 |
| 3 | UAB | 1 | 38 | 163 | 4.29 | 1 | 38.00 | 163.00 |
| 5 | Old Dominion | 1 | 41 | 164 | 4.00 | 2 | 41.00 | 164.00 |
| 6 | Florida International | 1 | 37 | 177 | 4.78 | 2 | 37.00 | 177.00 |
| 7 | Southern Mississippi | 1 | 33 | 211 | 6.39 | 1 | 33.00 | 211.00 |
| 8 | Middle Tennessee | 1 | 39 | 224 | 5.74 | 4 | 39.00 | 224.00 |
| 9 | North Texas | 1 | 39 | 306 | 7.85 | 3 | 39.00 | 306.00 |
| 10 | Rice | 2 | 85 | 672 | 7.91 | 10 | 42.50 | 336.00 |
| 11 | Charlotte | 2 | 94 | 689 | 7.33 | 5 | 47.00 | 344.50 |
| 12 | Florida Atlantic | 1 | 46 | 400 | 8.70 | 4 | 46.00 | 400.00 |