2021 Conference USA Leaders Scoring Defense - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Marshall | 12 | 38 | 12 | 35 | 0 | 0 | 299 | 24.9 |
| 2 | UTEP | 12 | 36 | 16 | 34 | 0 | 1 | 300 | 25.0 |
| 3 | UAB | 12 | 41 | 6 | 36 | 1 | 0 | 302 | 25.2 |
| 4 | UTSA | 13 | 44 | 14 | 37 | 1 | 0 | 345 | 26.5 |
| 5 | Middle Tennessee | 12 | 40 | 12 | 39 | 1 | 1 | 319 | 26.6 |
| 6 | Florida Atlantic | 11 | 37 | 10 | 33 | 3 | 2 | 295 | 26.8 |
| 7 | North Texas | 12 | 44 | 12 | 43 | 0 | 0 | 343 | 28.6 |
| 8 | Old Dominion | 12 | 43 | 18 | 40 | 1 | 0 | 354 | 29.5 |
| 9 | Western Kentucky | 13 | 50 | 14 | 48 | 0 | 0 | 390 | 30.0 |
| 10 | Southern Mississippi | 11 | 42 | 13 | 42 | 0 | 1 | 335 | 30.5 |
| 11 | Louisiana Tech | 11 | 47 | 12 | 44 | 1 | 1 | 366 | 33.3 |
| 12 | Charlotte | 11 | 54 | 7 | 51 | 1 | 0 | 398 | 36.2 |
| 13 | Rice | 11 | 53 | 9 | 51 | 0 | 2 | 400 | 36.4 |
| 14 | Florida International | 11 | 61 | 14 | 56 | 0 | 1 | 466 | 42.4 |