2021 Conference USA Leaders Scoring Defense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | UAB | 8 | 21 | 5 | 18 | 1 | 0 | 161 | 20.1 |
| 2 | Marshall | 8 | 23 | 8 | 21 | 0 | 0 | 183 | 22.9 |
| 3 | North Texas | 8 | 25 | 8 | 24 | 0 | 0 | 198 | 24.8 |
| 4 | UTEP | 8 | 26 | 6 | 25 | 0 | 0 | 199 | 24.9 |
| 5 | Old Dominion | 8 | 23 | 14 | 20 | 1 | 0 | 202 | 25.3 |
| 6 | Middle Tennessee State | 8 | 26 | 8 | 26 | 0 | 0 | 206 | 25.8 |
| 6 | UTSA | 9 | 30 | 9 | 23 | 1 | 0 | 232 | 25.8 |
| 8 | Western Kentucky | 9 | 31 | 6 | 29 | 0 | 0 | 233 | 25.9 |
| 9 | Southern Miss | 8 | 26 | 12 | 26 | 0 | 1 | 220 | 27.5 |
| 10 | Florida Atlantic | 8 | 27 | 9 | 24 | 3 | 2 | 223 | 27.9 |
| 11 | Louisiana Tech | 8 | 33 | 8 | 32 | 1 | 1 | 258 | 32.3 |
| 12 | Rice | 8 | 34 | 7 | 33 | 0 | 1 | 260 | 32.5 |
| 13 | Charlotte | 8 | 44 | 6 | 42 | 1 | 0 | 326 | 40.8 |
| 14 | FIU | 8 | 47 | 10 | 44 | 0 | 1 | 358 | 44.8 |