2021 Conference USA Leaders Scoring Defense - Games in November Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | North Texas | 4 | 7 | 4 | 7 | 0 | 0 | 61 | 15.3 |
| 2 | Western Kentucky | 4 | 11 | 1 | 11 | 0 | 0 | 80 | 20.0 |
| 3 | Old Dominion | 4 | 11 | 5 | 10 | 0 | 0 | 91 | 22.8 |
| 4 | Middle Tennessee | 4 | 12 | 5 | 12 | 0 | 0 | 99 | 24.8 |
| 5 | Southern Mississippi | 4 | 11 | 8 | 11 | 0 | 0 | 101 | 25.3 |
| 6 | UAB | 4 | 14 | 4 | 13 | 1 | 0 | 111 | 27.8 |
| 7 | Marshall | 4 | 14 | 6 | 13 | 0 | 0 | 115 | 28.8 |
| 8 | UTSA | 4 | 15 | 4 | 14 | 0 | 0 | 116 | 29.0 |
| 9 | UTEP | 4 | 17 | 5 | 17 | 0 | 0 | 134 | 33.5 |
| 10 | Florida Atlantic | 4 | 16 | 6 | 15 | 2 | 2 | 137 | 34.3 |
| 11 | Rice | 4 | 19 | 3 | 19 | 0 | 0 | 142 | 35.5 |
| 12 | Louisiana Tech | 4 | 21 | 2 | 20 | 1 | 0 | 154 | 38.5 |
| 13 | Charlotte | 4 | 24 | 1 | 24 | 0 | 0 | 171 | 42.8 |
| 14 | Florida International | 4 | 24 | 5 | 22 | 0 | 1 | 183 | 45.8 |