2021 Conference USA Leaders Scoring Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Charlotte | 4 | 11 | 2 | 10 | 0 | 0 | 82 | 20.5 |
| 2 | Florida Atlantic | 4 | 12 | 1 | 11 | 0 | 0 | 86 | 21.5 |
| 3 | UTSA | 5 | 14 | 5 | 14 | 0 | 0 | 113 | 22.6 |
| 4 | Marshall | 5 | 16 | 5 | 15 | 0 | 0 | 126 | 25.2 |
| 5 | Middle Tennessee | 5 | 16 | 4 | 14 | 2 | 1 | 128 | 25.6 |
| 6 | UTEP | 5 | 14 | 10 | 13 | 0 | 1 | 129 | 25.8 |
| 7 | UAB | 5 | 20 | 1 | 18 | 0 | 0 | 141 | 28.2 |
| 8 | Southern Mississippi | 4 | 16 | 1 | 16 | 0 | 0 | 115 | 28.8 |
| 9 | Florida International | 4 | 15 | 5 | 13 | 0 | 0 | 118 | 29.5 |
| 10 | North Texas | 5 | 21 | 4 | 21 | 0 | 0 | 159 | 31.8 |
| 10 | Old Dominion | 5 | 21 | 4 | 21 | 0 | 0 | 159 | 31.8 |
| 12 | Western Kentucky | 5 | 22 | 8 | 22 | 0 | 0 | 178 | 35.6 |
| 13 | Louisiana Tech | 4 | 20 | 4 | 18 | 0 | 0 | 150 | 37.5 |
| 14 | Rice | 4 | 23 | 4 | 22 | 0 | 1 | 174 | 43.5 |