2021 Conference USA Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Old Dominion | 1 | 164 | 188 | 70 | 352 | 5.03 | 352.0 |
| 2 | Louisiana Tech | 1 | 167 | 251 | 67 | 418 | 6.24 | 418.0 |
| 3 | UTSA | 1 | 156 | 333 | 76 | 489 | 6.43 | 489.0 |
| 4 | Marshall | 1 | 220 | 278 | 83 | 498 | 6.00 | 498.0 |
| 5 | Western Kentucky | 1 | 192 | 327 | 73 | 519 | 7.11 | 519.0 |
| 6 | Southern Mississippi | 1 | 211 | 395 | 59 | 606 | 10.27 | 606.0 |
| 7 | Rice | 2 | 389 | 377 | 133 | 766 | 5.76 | 383.0 |
| 8 | UAB | 2 | 362 | 571 | 118 | 933 | 7.91 | 466.5 |