2021 Conference USA Leaders Passing Defense - Games Lost Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Middle Tennessee State | 6 | 213 | 129 | 60.6 | 1519 | 7.1 | 15 | 5 | 139.01 | 35.5 | 253.2 |
| 2 | Florida Atlantic | 7 | 226 | 148 | 65.5 | 1719 | 7.6 | 12 | 5 | 142.48 | 32.3 | 245.6 |
| 2 | Old Dominion | 7 | 238 | 154 | 64.7 | 1797 | 7.6 | 19 | 3 | 151.95 | 34.0 | 256.7 |
| 4 | UTEP | 6 | 180 | 108 | 60.0 | 1409 | 7.8 | 9 | 1 | 141.15 | 30.0 | 234.8 |
| 4 | Marshall | 6 | 209 | 125 | 59.8 | 1639 | 7.8 | 11 | 2 | 141.14 | 34.8 | 273.2 |
| 6 | Louisiana Tech | 9 | 275 | 187 | 68.0 | 2179 | 7.9 | 19 | 6 | 153.00 | 30.6 | 242.1 |
| 7 | UTSA | 2 | 53 | 34 | 64.2 | 449 | 8.5 | 3 | 0 | 153.99 | 26.5 | 224.5 |
| 7 | North Texas | 7 | 208 | 134 | 64.4 | 1778 | 8.5 | 18 | 3 | 161.90 | 29.7 | 254.0 |
| 9 | Rice | 8 | 232 | 155 | 66.8 | 1987 | 8.6 | 17 | 5 | 158.63 | 29.0 | 248.4 |
| 9 | FIU | 11 | 345 | 242 | 70.1 | 2959 | 8.6 | 27 | 3 | 166.29 | 31.4 | 269.0 |
| 11 | Southern Miss | 9 | 230 | 149 | 64.8 | 2004 | 8.7 | 15 | 6 | 154.27 | 25.6 | 222.7 |
| 12 | Western Kentucky | 5 | 158 | 110 | 69.6 | 1401 | 8.9 | 11 | 1 | 165.80 | 31.6 | 280.2 |
| 13 | Charlotte | 7 | 168 | 117 | 69.6 | 1754 | 10.4 | 17 | 6 | 183.59 | 24.0 | 250.6 |
| 14 | UAB | 4 | 101 | 71 | 70.3 | 1235 | 12.2 | 14 | 1 | 216.78 | 25.3 | 308.8 |