2021 Conference USA Leaders Passing Defense - Games in December/January Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Middle Tennessee | 1 | 39 | 18 | 46.2 | 212 | 5.4 | 2 | 1 | 103.60 | 39.0 | 212.0 |
| 2 | UTEP | 1 | 41 | 26 | 63.4 | 286 | 7.0 | 1 | 0 | 130.07 | 41.0 | 286.0 |
| 3 | North Texas | 1 | 31 | 22 | 71.0 | 230 | 7.4 | 2 | 0 | 154.58 | 31.0 | 230.0 |
| 4 | Old Dominion | 1 | 34 | 22 | 64.7 | 285 | 8.4 | 2 | 0 | 154.53 | 34.0 | 285.0 |
| 5 | UAB | 1 | 23 | 15 | 65.2 | 195 | 8.5 | 0 | 0 | 136.44 | 23.0 | 195.0 |
| 6 | Marshall | 1 | 32 | 20 | 62.5 | 278 | 8.7 | 1 | 0 | 145.79 | 32.0 | 278.0 |
| 7 | Western Kentucky | 2 | 65 | 41 | 63.1 | 610 | 9.4 | 6 | 2 | 166.22 | 32.5 | 305.0 |
| 8 | UTSA | 2 | 96 | 60 | 62.5 | 910 | 9.5 | 7 | 2 | 162.01 | 48.0 | 455.0 |